"Stress B complex" is a whole product category. Here's what the trials actually found.
Written by Vita Globe Editorial Team | Reviewed against peer-reviewed research | Updated October 7, 2026
Quick Answer
A 2019 systematic review and meta-analysis found that B vitamin supplements modestly improved self-reported stress in healthy and at-risk adults. It found a possible benefit for depressive symptoms in at-risk groups and no clear effect on anxiety[1]. B6, B12 and folate are involved in making neurotransmitters[2], but a B complex is a small piece of managing stress, not a treatment for anxiety or depression.
In this article
Why are B vitamins linked to stress?
B6 helps make serotonin, dopamine and GABA. Folate and B12 are needed for methylation, a process involved in making and breaking down neurotransmitters. Low B12 and folate have been linked to mood problems in observational studies[2].
What does the research show?
Young and colleagues pooled randomized trials of B vitamin supplements lasting at least four weeks. They found:
- A small but significant improvement in stress scores in healthy and at-risk people
- A trend toward benefit for depressive symptoms, mainly in at-risk groups
- No significant effect on anxiety[1]
Most trials used multi-B formulas, often with other nutrients, so it's hard to say which vitamin did the work.
What are the limits?
The effects were modest, the trials were fairly short and they varied in dose and formula[1]. People who already have good B vitamin status may notice little. If stress, anxiety or low mood are affecting your daily life, talk to a doctor or mental health professional.
What else helps with stress?
- Regular sleep and wake times
- Daily movement, even short walks
- Breathing exercises (see Breathing Exercises for Stress and Sleep)
- Limiting caffeine and alcohol
- Talking to someone you trust
Our option
Vita Globe Vitamin B Complex Gummies
Six B vitamins, including B6, B12 and folate, in one daily gummy. Looking for a pairing? See the Mind & Mood Duo.
Frequently asked questions
Does stress deplete B vitamins?
This is often claimed, but there's limited direct evidence that everyday stress drains B vitamins.
Can B complex help with anxiety?
The 2019 meta-analysis didn't find a significant effect on anxiety[1].
Can I take B complex with antidepressants?
Ask your doctor or pharmacist before adding any supplement to a prescription.
Sources
- Young LM, Pipingas A, White DJ, Gauci S, Scholey A. A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals. Nutrients. 2019;11(9):2232. doi:10.3390/nu11092232
- Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy — A Review. Nutrients. 2016;8(2):68. doi:10.3390/nu8020068
About the Vita Globe Editorial Team
The Vita Globe Editorial Team researches and writes our wellness content from peer-reviewed research and guidance from bodies such as the NIH and FDA. We cite sources inline and update articles when the evidence changes.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This article is for informational purposes only and is not a substitute for medical advice. Talk to your healthcare provider before starting any new supplement, particularly if you are pregnant, nursing, taking medication, or managing a health condition.
